Southampton Women's have started the season in firing form winning their first three games in all competitions.
The Reds currently sit second in the table on goal difference following wins over Brislington and Swindon Town.
Tonight's opposition are just below Southampton in third but have had just as an impeccable start to the campaign.
Southampton FC Women beat Chesham and Brislington in the league ahead of the midweek clash.
Both teams will be keen to continue their fine starts and maintain their 100% records.
It's the Saints' debut season in the FA Women's National League following back to back promotions.
Marieanne Spacey-Cale has recruited well for the Saints bringing in players with higher level experience in the likes of Tiffany Taylor, Rachel Panting and Shannon Albuery all of whom have boosted the squad.
Shelly Povan, Saints' captain, is out with a season long injury so former Portsmouth midfielder Shannon Sievwright wears the arm band on match days and had the pick of the goals in their last win.
Last time out Saints beat Brislington 5-0 at AFC Totton, goals from Kelly-Marie Fripp, Georgie Freeland, Ella Pusey (brace) and Sievwright sealing the win.
Both managers are expected to field strong teams in the game with both sides eyeing promotion this season.
The two clubs have met once previously in the 2017/18 season in the Hampshire Cup semi-final.
Southampton were 4-0 winners on the night but due to an interpretation of the laws it was Saints who progressed to the final that season.
The game kicks off at 7:45pm at AFC Totton's Testwood Stadium with entry just £2 for adults and concessions are free.