A trip to Devon awaits Aaron Smith's Southampton side which will complete a busy start to September.
The reds are unbeaten in all competitions and it continued with a strong defensive display against Southampton FC on Wednesday night.
In front of a crowd of 557 Southampton took on the red and white side of the city for only the second time but there was very little to separate the sides.
Rose Kite made several good saves that denied Saints' attackers while Jane Yeates, Emily Wernham and Vinnie Nkomo were unable to convert their chances in the first-half.
Exeter were also in midweek action on Thursday when the hosted Buckland Athletic.
It wasn't the easiest of games for the newly promoted side they took an early 2-0 lead thanks to Kathryn Mundy and Abbie Britton before Sarah Stacey got a goal back for Buckland.
The visitors did have a goal disallowed in the game as Exeter's Ella-Mae Miller made it 3-1 but Sarah Smith made it an interesting final 15 minutes when she scored a second for Buckland.
Unable to find a third goal Athletic left Speeds Meadow empty handed and City rose to the top of the table.
Exeter manager Clive Watts will be pleased with his sides start to live in tier four winning their opening three and beating National League Souther Premier side Plymouth Argyle 4-3 in the League Cup.
They and Cheltenham are the only two yet to drop points in the FA Women's National League Division One South West but will face strong opposition when Southampton visit Speeds Meadow.
Between then the two sides have scored 27 goals in the league and conceded seven meaning spectators can expect a good battle on the pitch.
The Devonshire side are expected to be battling at the top of the table and so far they are fulfilling that role.
Also in action tomorrow are the Southampton Women's Reserves and Development Squad who both start their league campaigns.
The Reserves travel in Alton in the Southern Region while the Development Squad host Rushmoor Community.
Southampton Women's take on Exeter City on Sunday, September 8th at Speeds Meadow in the National League Division One South West.
After that it's a run of three home games as Southampton host Cheltenham Town, Buckland and Poole Town at Romsey Town FC.